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Saxena, Ajit Kumar
- Fruit Part of Momordica Charantia Possesses Remarkable in Vitro Anticancer Efficiency against Eight Human Cancer Cells
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Authors
Affiliations
1 Division of Biochemistry and Plant Physiology, Faculty of Agriculture, Sher-e-kashmir University of Agricultural Sciences and Technology of Main Campus Chatha, Jammu, J&K, IN
2 Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Jammu, J&K, IN
1 Division of Biochemistry and Plant Physiology, Faculty of Agriculture, Sher-e-kashmir University of Agricultural Sciences and Technology of Main Campus Chatha, Jammu, J&K, IN
2 Cancer Pharmacology Division, Indian Institute of Integrative Medicine, Jammu, J&K, IN
Source
International Journal of Plant Sciences, Vol 8, No 1 (2013), Pagination: 140-143Abstract
In vitro assay for cytotoxic activity of fruits obtained from Momordica charantia has been carried out against eight human cancer cell lines from six different tissues via methanolic and aqueous extract at the concentration of 100 g/ml. Results revealed that the 99 per cent methanolic extract suppressed the proliferation of seven human cancer cells. The most striking observations were 100 per cent growth inhibition against NCI-H322 (lung), 99 per cent growth inhibition against MCF-7 (breast) and 97 per cent growth inhibition on COLO-205 (colon) cancer cells. However, aqueous extract from the floral part of the plant showed activity (74%) against HCT-116 (colon). Based on the in vitro data, it is suggested that consumption of the components of this plant or ingestion of methanolic extract as tea may impart anticancer effects especially in the lung, breast, colon and will be evaluated for the possible isolation of active antitumor compounds.Keywords
Momordica Charantia, Methanolic Extract, in Vitro Cytotoxic, Cancer Cells- Antenatal Exposure of Cyclophosphamide Affects Cell Proliferation in Seminiferous Tubules (Gonocytes and Sertoli Cells) in Neonatal Rat Testis
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Authors
Affiliations
1 Center of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Vraranasi-221005, IN
1 Center of Experimental Medicine & Surgery, Institute of Medical Sciences, Banaras Hindu University, Vraranasi-221005, IN
Source
Journal of Endocrinology and Reproduction, Vol 13, No 2 (2009), Pagination: 51-56Abstract
The present study demonstrates the changes in the distribution and number of cellular contents of seminiferous tubules (Sertoli cells and gonocytes) in rat testis after exposure to different doses of cyclophosphamide (2, 10 or 20 mg/kg body wt) on day 12, 15 and 18 of gestation. The treatment caused significant decrease of these parameters. Besides, morphological changes such as discontinuity of epithelial lining and basement membrane of seminiferous tubules, and stunting of Sertoli cells and gonocytes were also observed in the pups in a dose-dependent manner. Reduction (p<0.001) in the number of gonocytes was observed on day 15 of gestation and Sertoli cells on day 18. These days of embryonic development / gestation may be considered as "critical periods" for cell proliferation during the differentiation of male gonad. Overall, our data suggest that antenatal exposure to cyclophosphamide may affect the normal process of testicular development.Keywords
Cyclophosphamide, Gonocyte, Maternal Exposure, Sertoli Cell, Testis.- In Vitro Cytotoxicity of Extracts and Fractions from Aerial Parts of Calotropis procera Against CNS Cancer Cell Line
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Authors
Affiliations
1 School of Biotechnology, University of Jammu, Jammu (J & K), IN
2 Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar (Punjab), IN
3 Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi (J & K), IN
1 School of Biotechnology, University of Jammu, Jammu (J & K), IN
2 Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar (Punjab), IN
3 Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi (J & K), IN
Source
Asian Journal of Bio Science, Vol 4, No 1 (2009), Pagination: 69-72Abstract
Calotropis procera (Ait.) R.Br., a popular medicinal species in Indian system of medicine, is widely used for the treatment of various diseases. In the present investigation the cytotoxicity of the three extracts and their fractions from aerial parts of Calotropis procera was evaluated against central nervous system (SNB-78) human cancer cell line. The results showed that hydro-alcohloic extract has more potential at three different concentrations of 10, 30 and 100 μg/ml, among all the three extracts viz., alcoholic, hydro-alcoholic and aqueous extracts. On evaluation of the various fractions, n-butanol fraction of both hydro-alcoholic and alcoholic extracts had shown antiproliferative activity against human cancer cell line of central nervous system (SNB-78) at three different concentrations of 10 and 30 μg/ml. Aqueous extract was found to be least active.Keywords
Calotropis Procera, Aerial Parts, Extracts, Fractions, Cytotoxicity, Human Cancer Cell Line.- Studies on in vitro cytotoxicity of Ficus hispida Leaves
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Authors
Affiliations
1 Department of Biotechnology, University of Jammu, Jammu (J&K), IN
2 Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar (Punjab), IN
3 Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, Jammu (J&K), IN
1 Department of Biotechnology, University of Jammu, Jammu (J&K), IN
2 Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar (Punjab), IN
3 Pharmacology Division, Indian Institute of Integrative Medicine, Canal Road, Jammu (J&K), IN